Maximal enzymatic activity per gram tissue of pyruvate kinase (PK; A), lactate dehydrogenase (LDH; B), citrate synthase (CS; C), carnitine palmitoyl transferase (CPT; D), and 3-hydroxyacyl CoA dehydrogenase (HOAD; E) in the tissues of normoxic controls and hypoxia-acclimated naked mole-rats. Values are means ± SE (n = 12 mole-rats in normoxia and n = 9 mole-rats in hypoxia). **P < 0.01 and ***P < 0.001, significant effects of hypoxia.