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. 2020 Jul 27;319(2):F345–F357. doi: 10.1152/ajprenal.00032.2020

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Fig. 5. — Expression of hypoxia-inducible factor (HIF)-α and prolyl hydroxylases (PHDs) in the kidney. A and B: expression of HIF-1α and HIF-2α was increased in wild-type (WT) mice infused with angiotensin II (ANG II), whereas knockout (KO) of endothelial PHD2 significantly suppressed these increases in both the renal cortex and medulla. C: ANG II infusion downregulated the expression of PHD1 in both the cortex and medulla, whereas KO of endothelial PHD2 prevented this decline. D and E: there were no statistical differences in expression of PHD2 or PHD3. PHD2^ECKO, endothelial PHD2-specific KO. Male mice at 16 wk of age were used; n = 3–4 mice/group. *P < 0.05; **P < 0.01.

Fig. 5. — Expression of hypoxia-inducible factor (HIF)-α and prolyl hydroxylases (PHDs) in the kidney. A and B: expression of HIF-1α and HIF-2α was increased in wild-type (WT) mice infused with angiotensin II (ANG II), whereas knockout (KO) of endothelial PHD2 significantly suppressed these increases in both the renal cortex and medulla. C: ANG II infusion downregulated the expression of PHD1 in both the cortex and medulla, whereas KO of endothelial PHD2 prevented this decline. D and E: there were no statistical differences in expression of PHD2 or PHD3. PHD2^ECKO, endothelial PHD2-specific KO. Male mice at 16 wk of age were used; n = 3–4 mice/group. *P < 0.05; **P < 0.01.