Fig. 7.

A and B: insulin (I) during intravenous glucose tolerance tests performed at the time points indicated by the black dots in Fig. 1C [A; impaired glucose tolerance (IGT)-first pathway] and Fig. 3C [B; impaired fasting glucose (IFG)-first pathway]. C and D: readily releasable pool (RRP) size (numbers of vesicles) corresponding to A and B, respectively. Decline of acute insulin response to glucose (AIRg) parallels the reduction of RRP for each case. CGI, combined glucose impairment; NGT, normal glucose tolerance; T2D, type 2 diabetes.