Table 2.
Echocardiographic measurements and postmortem analysis of LV mass in male WT and Bmp3b−/− mice at 6 mo of age
| WT (n = 8) | Bmp3b−/− (n = 8) | P | |
|---|---|---|---|
| HR, beats/min | 441 ± 11 | 458 ± 7 | 0.241 |
| LVEF, % | 58 ± 1 | 53 ± 2 | 0.037 |
| PWT, mm | 0.68 ± 0.02 | 0.67 ± 0.03 | 0.895 |
| IVS, mm | 0.74 ± 0.02 | 0.68 ± 0.03 | 0.104 |
| LVEDD, mm | 3.7 ± 0.1 | 4.1 ± 0.1 | 0.002 |
| LVESD, mm | 2.6 ± 0.1 | 2.9 ± 0.1 | 0.014 |
| LVEDV, µL | 55 ± 1 | 72 ± 3 | <0.0001 |
| LVESV, µL | 23 ± 1 | 33 ± 2 | <0.001 |
| SV, µL | 32 ± 1 | 38 ± 2 | 0.015 |
| CO, mL/min | 14 ± 1 | 17 ± 1 | 0.007 |
| RWT, % | 0.38 ± 0.01 | 0.33 ± 0.02 | 0.013 |
| LVW/BW, mg/g | 3.7 ± 0.1 | 4.4 ± 0.2 | 0.031 |
| LVW/TL, mg/mm | 5.3 ± 0.1 | 6.7 ± 0.3 | 0.001 |
Data represent means ± SE for n mice. Bmp3b−/−, Bmp3b knockout; BW, body weight; CO, cardiac output; HR, heart rate; IVS, end-diastolic interventricular septal thickness; LVEDD, left ventricular (LV) end-diastolic internal diameter; LVEDV, LV end-diastolic internal volume; LVEF, LV ejection fraction; LVESD, LV end-systolic internal diameter; LVESV, LV end-systolic internal volume; LVW, LV weight; PWT, end-diastolic posterior wall thickness; RWT, relative wall thickness; SV, stroke volume; TL, tibia length; WT, wild type.