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. 2020 Jun 23;319(2):E338–E344. doi: 10.1152/ajpendo.00088.2020

Fig. 5.

Fig. 5.

Islets from βNUPR1 mice were less susceptive to culture stress and IL-1β. Isolated islets from ~3-mo-old normal-fed mice were exposed for 2–8 days to culture stress (A–C) or for 24 h to 10 ng/ml IL-1β on culture day 4 (D–F) before measurement of glucose-induced insulin secretion/content and PARP cleavage. A: insulin secretion after 1-h incubation with 2.8 and 20 mM glucose (n = 4–5). B: insulin content in islets from A. C: PARP cleavage (n = 4). D: insulin secretion after 1-h incubation with 2.8 and 20 mM glucose (n = 6–8). E: insulin content in islets from D. F: PARP cleavage (n = 5). Data are box plots with min/max whiskers. *P < 0.05, **P < 0.01, and ***P < 0.001 [wild-type (WT) vs. transgenic (Tg)]; aaaP < 0.001 (2.8 vs. 20 mM); bP < 0.05, bbP < 0.01, and bbbP < 0.001 (day 2 vs. day 8 or Con vs. IL-1β).