Fig. 4.

Mitochondrial respiration relative to changes in cell volume induced by HFD feeding at 8 wk in iWAT. Adipocyte cell volume (A), carbohydrate-supported (B), and lipid-supported (C) mitochondrial respiration in iWAT (n = 4–6/experiment). Open bars denote LFD-fed mice, while solid bars denote HFD-fed mice. Data are expressed as means ± SE *P < 0.05 compared with LFD group. DNP, 2,4-dinitrophenol; Glut, glutamate; G3P, glycerol-3-phosphate; iWAT, inguinal white adipose tissue; JO₂, oxygen flux; P-CoA, palmitoyl-CoA; Pyr, pyruvate; Succ, succinate.