Fig. 9.

Schematic representation of increased fibrotic deposition of collagen in left ventricular pressure overload (LVPO)-inducing increases in organ-specific factors such as CC ligand (CCL)-11 and -12 in the myocardium as well as increases in circulating cytokines and chemokines, including CCL-21 and granulocyte macrophage-colony stimulating factor (GM-CSF). The majority of factors increased in 1-wk LVPO returned to baseline levels at 4 wk. Evidence for activated endothelium [intercellular adhesion molecule (ICAM) + staining] was strongest at 1 wk, but persistent increases over sham were observed at 4-wk LVPO.