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. 2020 May 27;319(2):L228–L238. doi: 10.1152/ajplung.00473.2019

Fig. 1.

Fig. 1.

A: diaphragm-specific force generation (i.e., force per cross-sectional area) is shown as a function of phrenic nerve stimulation frequency. Data represent values for the following groups: sham control (black symbols; n = 6), cecal ligation puncture (CLP; red symbols; n = 7), sham control + MitoTEMPOL (green symbols; n = 3), and CLP + MitoTEMPOL (blue symbols; n = 3). B: diaphragm force is shown as a function of direct muscle electrical field stimulation frequency (n = 7 for controls, n = 7 for CLP, n = 5 for MitoTEMPOL, and n = 6 for CLP + MitoTEMPOL). Symbols represent group mean results and error bars represent 1 SE. CLP-induced sepsis produced a large reduction in diaphragm force generation, with either phrenic or direct muscle stimulation, at all excitation frequencies when compared with values for controls (P < 0.01 for comparison at each frequency). MitoTEMPOL administration prevented sepsis-induced reductions in diaphragm force, with diaphragm-specific force for the CLP + MitoTEMPOL group higher for CLP. Force generation for the control + MitoTEMPOL group was similar to that for the control group (not significant). *Statistical significance when compared with other groups.