Skip to main content
. 2020 May 27;319(2):L228–L238. doi: 10.1152/ajplung.00473.2019

Fig. 7.

Fig. 7.

A: delayed administration of MitoTEMPOL (blue) was as effective as immediate postsurgical administration of MitoTEMPOL (green) in preventing sepsis-induced reductions in diaphragm force generation. [P < 0.001 for comparison of both cecal ligation puncture (CLP) + immediate MitoTEMPOL and CLP + delayed MitoTEMPOL groups to CLP alone]. Data were obtained for controls (n = 7), CLP (n = 7), immediate MitoTEMPOL (n = 5), and delayed MitoTEMPOL (n = 4) groups. Boxes represent 1 SE, center line in the box indicates the mean, and whiskers indicate the minimum and maximum values. B: demonstration that these effects of delayed MitoTEMPOL administration were maintained across all excitation frequencies and were significantly different when compared with values for septic animals (n = 7 control, n = 7 CLP, immediate n = 4 MitoTEMPOL, and n = 4 delayed MitoTEMPOL groups). *Statistical significance.