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. 2020 Jul 9;129(2):272–282. doi: 10.1152/japplphysiol.00381.2020

Fig. 5.

Fig. 5.

E3 Ubiquitin ligases expressed in skeletal muscle. There are over 600 E3 ligases in the human genome and they can be broadly classified into two types: RING finger E3s and the cullin-RING E3 ligase (CRL) superfamily. MuRF1 belongs to the Ring finger E3 family and MAFbx belongs to the cullin-RING E3 superfamily. MuRF1 (Trim63) and MAFbx (Fbxo32) represent just two of the many E3 ligases expressed in skeletal muscle. The majority of RING finger E3s (A) and cullin-RING E3s (B) expressed in skeletal muscle have not been studied in any detail.