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. 2020 Aug 25;12:285–300. doi: 10.2147/JEP.S256586

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© 2020 Yu et al.

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Effects of viloxazine on uptake and cellular functional activity in vitro. (A) Dose-dependent inhibition of NET-mediated [³H]-NE uptake (n = 3) measured in rat hypothalamic synaptosomes and [³H]-5-HT uptake (n = 3) measured in HEK293 cells expressing hSERT. (B) Viloxazine activated the response of 5-HT_2C (agonist) in a CHO cell-based IP₁ HTRF^® assay (n = 2). (C) Viloxazine antagonized the activity of 5-HT_2B after stimulation with 5-HT in a CHO cell-based IP₁ HTRF^® assay (n = 2). Data presented as mean ± SEM.

Abbreviations: 5-HT, serotonin; CHO, Chinese hamster ovary; DA, dopamine; EC₅₀, concentration producing a half-maximal response; HEK, human embryonic kidney; hSERT, human serotonin transporter gene; HTRF, homogeneous time-resolved fluorescence; IC₅₀, concentration causing a half-maximal inhibition of control response; IP₁, inositol phosphate-1; NE, norepinephrine; NET, norepinephrine transporter; SEM, standard error of the mean; SERT, serotonin transporter.