Table 2.
Characteristics of Study Population Between ICS Users and Nonusers Before and After Propensity Score Matching
| Overall Patients | After Propensity Score Matching | |||||
|---|---|---|---|---|---|---|
| ICS User (n=250) | ICS Nonuser (n=368) | p-value | ICS User (n=239) | ICS Nonuser (n=239) | p-value | |
| Age, year | 69.0±8.4 | 68.3±7.5 | 0.272 | 69.0±8.3 | 69.1±7.1 | 0.827 |
| Sex, Male (%) | 242 (97) | 358 (97) | 0.915 | 231 (97) | 232 (97) | 1.000 |
| Height, cm | 164±6 | 165±5 | 0.224 | 165±6 | 164±6 | 0.927 |
| Current smoker (%) | 187 (75) | 258 (70) | 0.336 | 176 (74) | 175 (73) | 1.000 |
| Eosinophil,/µL | 212±156 | 234±175 | 0.108 | 213±158 | 226±166 | 0.352 |
| LA inhalers use, n (%) | – | – | ||||
| None Single Dual Triple |
0 (%) 3 (1%) 86 (34%) 161 (64%) |
168 (46%) 147 (40%) 53 (14%) 0 (0%) |
0 (%) 3 (1%) 85 (35%) 151 (63%) |
106 (44%) 98 (41%) 35 (15%) 0 (0%) |
||
| Spirometry | ||||||
| Post-BD FEV1, L Post-BD FEV1, % pred |
1.47±0.53 57.0±19.6 |
1.70±0.52 65.2±18.3 |
<0.001* <0.001* |
1.48±0.53 57.4±19.7 |
1.54±0.46 60.5 ±17.6 |
0.190 0.066 |
| Symptom | ||||||
| mMRC dyspnea scale | 1.68±0.86 | 1.33±0.83 | <0.001* | 1.67±0.87 | 1.55±0.82 | 0.131 |
| History of AE-COPD | ||||||
| AE rate, events/year Incidence of AE, n (%) |
0.65±1.55 67 (27) |
0.48±1.73 74 (20) |
0.225 0.059 |
0.66±1.57 65 (27) |
0.56±1.96 53 (22) |
0.520 0.243 |
Notes: *Matching variables: post-BD FEV1(L), mMRC dyspnea scale, AECOPD. Mean ± standard deviation, p-value < 0.05.
Abbreviations: BD, bronchodilator; LA inhaler, long-acting inhaler; ICS, inhaled corticosteroids; FEV1, forced expiratory volume in 1 second; mMRC, the modified Medical Research Council; AE, acute exacerbation.