Table 2.
Identification and Function of Previously Established PGC-1α Target Genes
| Gene | GC ID | Tissue | Reference | Function |
|---|---|---|---|---|
| Ppargc1a | GC04M023755 | Muscle | (Handschin et al., 2003) | Transcription |
| Ppara | GC22P046150 | Adipose | (Mazzucotelli et al., 2007) | Transcription |
| Pparg | GC03P012328 | Muscle | (Zhang et al., 2007) | Transcription |
| Nrf1 | GC07P129611 | Muscle | (Wu et al., 1999) | Transcription |
| Esrra | GC11P064305 | Muscle | (Lin et al., 2004) | Transcription |
| Srebf1 | GC17M017810 | Liver | (Oberkofler et al., 2004) | Transcription |
| Pck1 | GC20P057561 | Liver | (Yoon et al., 2001) | Gluconeogenesis |
| G6pc | GC17P042900 | Liver | (Yoon et al., 2001) | Gluconeogenesis |
| Cpt1a | GC11M068772 | Liver | (Zhang et al., 2004) | FA oxidation |
| Cpt1b | GC22M050569 | Muscle | (Kleiner et al., 2009) | FA oxidation |
| Acadm | GC01P075724 | Liver | (Rhee et al., 2003) | FA oxidation |
| Tfam | GC10P058385 | Muscle | (Wu et al., 1999) | Biogenesis/ETC |
| Atp5b | GC12M056639 | Muscle | (Puigserver et al., 2001) | Biogenesis/ETC |
| ATP5g1 | GC17P048893 | Muscle | (Gerhart-Hines et al., 2007) | Biogenesis/ETC |
| NdufA2 | GC05M140607 | Adipose | (Bai et al., 2011) | Biogenesis/ETC |
| Cox4i1 | GC16P085833 | Muscle | (Puigserver et al., 2001) | Biogenesis/ETC |
| Cycs | GC07M025158 | Muscle | (Puigserver et al., 2001) | Biogenesis/ETC |
| Pdk1 | GC02P172555 | Muscle | (Gudiksen and Pilegaard, 2017) | Pyr. metabolism |
| Pdk2 | GC17P050095 | Muscle | (Gudiksen and Pilegaard, 2017) | Pyr. metabolism |
| Pdk3 | GC0XP024393 | Kidney | (Degenhardt et al., 2007) | Pyr. metabolism |
| Pdk4 | GC07M095583 | Muscle | (Kleiner et al., 2009) | Pyr. metabolism |
| Mfn2 | GC01P011980 | Muscle | (Cartoni et al., 2005) | Morphology |
| Ucp1 | GC04M140559 | Adipose | (Puigserver et al., 1998) | Thermogenesis |
| Slc1a5 | GC19M046760 | Breast cancer | (McGuirk et al., 2013) | AA metabolism |
| Gpt2 | GC16P046885 | Breast cancer | (McGuirk et al., 2013) | AA metabolism |
| Gls | GC02P190880 | Breast cancer | (McGuirk et al., 2013) | AA metabolism |
| Gls2 | GC12M056470 | Breast cancer | (McGuirk et al., 2013) | AA metabolism |
| Glul | GC01M182350 | Breast cancer | (McGuirk et al., 2013) | AA metabolism |
| Got1 | GC10M099396 | Breast cancer | (McGuirk et al., 2013) | AA metabolism |
| Got2 | GC16M058707 | Breast cancer | (McGuirk et al., 2013) | AA metabolism |
| Glud1 | GC10M087050 | Breast cancer | (McGuirk et al., 2013) | AA metabolism |
GC ID, gene card ID; FA, fatty acid; ETC, electron transport chain; Pyr., pyruvate; AA, amino acid.
Previous studies were utilized to compile a list of target genes potentially regulated by PGC-1α in NK cells. Genes from studies using different cell types and metabolic stresses were considered. The list contains genes responsible for varying aspects of mitochondrial function to account for various potential outcomes of PGC-1α-mediated regulation in NK cells. Genes are listed by italicized gene symbol in the table.