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. 2020 Sep 4;11:4417. doi: 10.1038/s41467-020-18233-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a The inhibitory effect of Boceprevir and GC376 treatment on SARS-CoV-2 replication. Remdesivir was used as a positive control. b The relative concentration of viral RNA present in the supernatant at 72h post infection determined by Real-time quantitative PCR analysis after Boceprevir and GC376 treatment, unpaired t test for comparison of relative viral RNA copies incubated with inhibitor vs virus control (n = 3 independent replicates). p = 0.0036, 0.6474, 0.0003 for 8 μM Boceprevir, 0.32 μM GC376, and 0.8 μM Remdesivir, respectively (ns: not significant P > 0.05, **P < 0.01, ***P < 0.001). c–f Virus-induced cytopathic effect in Vero cells after Boceprevir and GC376 treatment. Scale bar represents 100 μm. Error bars: mean ± S.D. of three independent replicates. Source data are provided as a source data file.