Supplementary Table 1.
Summary of Means ± Standard Error of 4 Parameters of Spontaneous Contractions of Circular Muscle Layers of Human Sigmoid Colon for 10 Minutes After Adding Norepinephrine 1 μmol/L and 10 μmol/L to Organ Baths
| AUC (mN·min) |
Amplitude (mN) |
Tone (mN) |
Freq (cont/min) |
|||||
|---|---|---|---|---|---|---|---|---|
| Nor 1 μmol/L | Nor 10 μmol/L | Nor 1 μmol/L | Nor 10 μmol/L | Nor 1μmol/L | Nor 10 μmol/L | Nor 1 μmol/L | Nor 10 μmol/L | |
| None (4)a | 69.65 ± 9.55 | 24.67 ± 4.94 | 9.54 ± 1.44 | 1.66 ± 0.66 | 2.95 ± 0.64 | 1.86 ± 0.54 | 3.6 ± 0.6 | 3.2 ± 0.3 |
| TTX (5) | 77.68 ± 15.19 | 28.80 ± 7.34 | 14.84 ± 2.82 | 3.26 ± 1.33 | 2.64 ± 0.61 | 1.95 ± 0.47 | 3.0 ± 0.2 | 2.8 ± 0.3 |
| TTX + Prop (11) | 84.70 ± 15.49 | 32.88 ± 5.26 | 12.08 ± 1.95 | 2.40 ± 0.58 | 3.57 ± 0.92 | 2.35 ± 0.40 | 4.3 ± 0.5 | 4.2 ± 0.3 |
| TTX + Prop + Praz (5) | 48.99 ± 7.64 | 36.96 ± 7.52 | 8.36 ± 1.97 | 6.44 ± 1.31 | 1.58 ± 0.54 | 1.40 ± 0.48 | 3.8 ± 0.7 | 3.9 ± 0.6 |
| TTX + Prop + RS (8) | 65.87 ± 8.95 | 101.30 ± 14.88 | 12.50 ± 1.17 | 13.98 ± 1.29 | 2.13 ± 0.37 | 3.74 ± 0.85 | 3.9 ± 0.4 | 3.8 ± 0.3 |
| TTX + Prop + BMY (8) | 49.53 ± 3.71 | 28.21 ± 4.07 | 9.59 ± 0.77 | 3.33 ±1 .18 | 1.89 ± 0.22 | 1.79 ± 0.17 | 3.8 ± 0.4 | 4.3 ± 0.5 |
| TTX + Prop + Apa (8) | 86.97 ± 10.30 | 71.94 ± 12.03 | 13.42 ± 1.87 | 9.88 ± 1.32 | 2.89 ± 0.71 | 3.08 ± 0.90 | 4.2 ± 0.3 | 4.5 ± 0.3 |
Apa, apamin 100 nmol/L; AUC, area under the curve; BMY, BMY7378 1 μmol/L; cont, contractions; Freq, frequency; Nor, noradrenaline; Praz, prazosin 1 μmol/L; Prop, propranolol 1 μmol/L; RS, RS100329 1 μmol/L; TTX, tetrodotoxin 1 μmol/L.
a
Numbers in parentheses represent number of patients in each of the protocols.