Table 2.

BAs induce neither contraction nor relaxation in unstimulated (resting) airways

BA	Human	Mouse
DMSO	−2.6 ± 2.7	−1.9 ± 0.2
CA	−5.3 ± 1.8	−0.5 ± 0.3
GCA	ND	−1.3 ± 0.7
TCA	ND	0.4 ± 0.4
CDCA	ND	−1.7 ± 1.0
GCDCA	ND	−0.4 ± 0.4
TCDCA	ND	0.1 ± 0.5
LCA	ND	−0.2 ± 3.2
GLCA	ND	6.4 ± 1.2
TLCA	−2.7 ± 3.7	1.0 ± 0.5
DCA	ND	−1.1 ± 0.5
GDCA	−5.2 ± 1.4	−0.6 ± 0.4
TDCA	ND	−0.3 ± 0.4
UDCA	ND	−0.2 ± 0.4

Values are means ± SE of 3–5 precision-cut lung slices (PCLS) from 3 human lungs or 6–8 PCLS from 3 mice. Summary of decrease (+) or increase (−) in airway lumen area (%) induced by exposure of the PCLS to bile acids (BA; tested at 30 μM) or 0.1% DMSO (vehicle) in human and mouse peripheral airways at rest. The data were obtained from experiments similar to those shown in Fig. 1, A and D. There were no significant differences between groups; α = 0.05, one-way ANOVA. CA, cholic acid; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; GCA, glycocholic acid; GCDCA, glycochenodeoxycholic acid; GDCA, glycodeoxycholic acid; LCA, lithocholic acid; ND, not determined; TCA, taurocholic acid; TCDCA, taurochenodeoxycholic acid; TDCA, taurodeoxycholic acid; TLCA, taurolithocholic acid; UDCA, ursodeoxycholic acid.