Table 1.
General comparison of patients with nondialysis chronic kidney disease with and without ESA therapy at baseline
| ESA Group | Non-ESA Group | P Value | |
|---|---|---|---|
| n | 35 | 42 | |
| Sex, n (%) | 0.24 | ||
| Women | 18 (51) | 16 (38) | |
| Men | 17 (49) | 26 (62) | |
| Age, yr | 61 ± 12 | 56 ± 14 | 0.07 |
| Body mass index, kg/m2 | 34 ± 7 | 33 ± 8 | 0.89 |
| Estimated glomerular filtration rate, mL·min−1·1.73 m−2* | 26.2 ± 10.1 | 33.5 ± 14.3 | 0.01 |
| Creatinine, mg/dL | 3.1 ± 1.9 | 2.4 ± 0.9 | 0.08 |
| Chronic kidney disease etiology, n (%) | 0.45 | ||
| Diabetes mellitus | 14 (40) | 16 (38) | |
| Hypertension | 14 (40) | 19 (45) | |
| Chronic glomerulonephritis | 6 (17) | 4 (10) | |
| Chronic tubulointerstitial nephritis | 1 (3) | 1 (2) | |
| Autosomal dominant polycystic kidney disease | 2 (5) | ||
| Smoker, n (%) | 6 (17) | 5 (12) | 0.51 |
| Renin-angiotensin-aldosterone system blockers, n (%) | 29 (83) | 34 (81) | 0.83 |
| Iron therapy, n (%)* | 30 (86) | 27 (64) | 0.03 |
| Left ventricular hypertrophy, n (%) | 11 (31.5) | 13 (31) | 0.96 |
| Hemoglobin, g/dL* | 11.1 ± 0.9 | 12.5 ± 1.2 | <0.001 |
| Hematocrit, %* | 33 ± 5 | 36 ± 6 | 0.04 |
| Mean corpuscular volume, fL | 88.7 ± 5.2 | 88.1 ± 3.5 | 0.55 |
| Mean corpuscular hemoglobin, pg | 31.5 ± 1.4 | 31.9 ± 1.1 | 0.27 |
| Ferritin, µg/L | 137.1 ± 23.2 | 86.3 ± 11.4 | 0.08 |
| Transferrin saturation, % | 24.1 ± 1.8 | 26.9 ± 2.7 | 0.16 |
| Serum iron levels, µg/dL | 82.1 ± 4.5 | 79.2 ± 5.4 | 0.65 |
| Serum erythropoietin levels, mU/mL | 12.4 ± 6.8 | 10.7 ± 5.1 | 0.49 |
| Serum soluble Fas levels, pg/mL* | 4316 ± 897 | 2776 ± 749 | <0.001 |
| Intact parathyroid hormone levels, pg/mL | 128 ± 24 | 165 ± 30 | 0.36 |
| IL-6 levels, pg/mL | 6.4 ± 4.1 | 7.6 ± 5.4 | 0.38 |
| IL-10 levels, pg/mL | 13.1 ± 7.3 | 12.1 ± 6.4 | 0.52 |
| Albumin, g/dL | 3.6 ± 0.35 | 4.1 ± 0.77 | 0.06 |
Values are means ± SD; n, number of patients/group. The estimated glomerular filtration rate was calculated by the Chronic Kidney Disease Epidemiology Collaboration equation. ESA, erythropoiesis-stimulating agent.
*
P < 0.05.