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Ontogeny of intercalated cell (IC) differentiation. ICs and principal cells (PCs) are derived from a common immature precursor (epithelial precursor cell) that is governed by Notch and Foxi1 signaling. In the absence of Notch signaling, the transcription factor Foxi1 is suppressed. However, the “terminal” phenotype of the various IC subtypes may interconvert under certain experimental conditions.
