FIGURE 9.

α-Ketoglutarate (αKG) signal transduction pathway in intercalated cells (ICs). αKG acts on the OXGR1 receptor, which stimulates protein kinase C (PKC)-α through a Ca²⁺-dependent mechanism and stimulates PKC-δ to increase pendrin-dependent Cl⁻ absorption. The role of other type B IC transporters, known to modulate apical anion exchange, in αKG-induced Cl⁻ absorption is unknown. DAG, diacylglycerol; IP₃, inositol 1,4,5-trisphosphate; PLC, phospholipase C. [Modified from Lazo-Fernandez et al. (103).]