Table2.

The Functions and Mechanisms of Macrophage-Derived Exosomes on Cancer Cells

Cancer	Molecule	Mechanism	Function	References
HCC	miR-125	–	promoting invasion	81
	miR-142, miR-223	–	inhibiting proliferation	89
PDAC	miR-501-3p	inhibiting TGFBR3, activating TGF-β signal	promoting invasion	83
	miR-365	–	inducing resistance against gemcitabine	90
Colon cancer	miR-21, miR-155	downregulating BRG1	promoting metastasis	86
Breast cancer	miR-233	Mef2c/β-catenin	promoting invasion	88
	IL-6	STAT3 pathway	promoting proliferation and metastasis	91
	ADAM15	inhibiting avβ3	inhibiting adhesion, growth and migration	92
Recipient gastric cancer	ApoE	PI3K/AKT	promoting migration	93
	miR-21	–	inducing resistance against DDP	94
Glioblastoma	miR-21	targeting PDCD4	inducing resistance against temozolomide	95
		modulating PEG3	inducing immune evasion	96
EOC	miR-223	PTEN-PI3K/AKT	inducing chemotherapy resistance	78
	miR-29a-3p, miR-21-5p	upregulating Treg/Th17 ratio	inducing immune evasion	97

–, unknown