Table 2.
Immune-related nodes in the SQD syndrome biomolecular network.
| Top 20 biomolecules | Degree | Biological process and pathway |
|---|---|---|
| PIK3R1 | 29 | T cell receptor signaling pathway |
| MAPK14 | 27 | T cell receptor signaling pathway |
| LCK | 27 | Natural killer cell-mediated bioactivity |
| JUN | 26 | B cell receptor signaling pathway |
| GRB2 | 25 | T cell receptor signaling pathway |
| MAPK1 | 24 | T cell receptor signaling pathway |
| AKT1 | 24 | B cell receptor signaling pathway |
| MAPK8 | 24 | Helper T cell proliferation and differentiation |
| SMAD3 | 23 | T cell receptor signaling pathway |
| FYN | 23 | Natural killer cell-mediated bioactivity |
| RELA | 23 | B cell receptor signaling pathway |
| HSP90AA1 | 23 | Antigen processing and presentation |
| CTNNB1 | 21 | Antigen processing and presentation |
| SHC1 | 20 | Natural killer cell-mediated bioactivity |
| TGFBR1 | 20 | Helper T cell proliferation and differentiation |
| JAK2 | 17 | Helper T cell proliferation and differentiation |
| FOS | 17 | B cell receptor signaling pathway |
| MAP3K7 | 17 | B cell receptor signaling pathway |
| NFKB1 | 17 | Leukocyte transendothelial migration |
| MAPK3 | 16 | T cell receptor signaling pathway |