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. 2020 Aug 27;2020:7413693. doi: 10.1155/2020/7413693

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Copyright © 2020 Xue Han et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

MG53 alleviated myocardial inflammation in SIMD rats, which was exacerbated by GW6471. Collagen accumulation was demonstrated by (a) Masson's trichrome staining. Collagen was stained blue in paraffin-embedded heart tissue sections (400x magnification, scale bar = 50 μm) and (b) the quantitation of interstitial fibrosis area (%). Inflammatory cytokines (c) interleukin-1β (IL-β), (d) IL-6, and (e) tumor necrosis factor-α (TNF-α) in serum were detected by ELISA, and (f) cyclooxygenase-2 (COX-2) expression in the myocardium was detected by western blotting. Data are presented as mean ± SD, n = 8. ^∗P < 0.05, ^∗∗P < 0.01, and ^∗∗∗P < 0.001. CLP = cecal ligation and puncture; rhMG53 = recombinant human mitsugumin-53.