Table 1.
Echocardiographic data for sham, TAC, TAC + T, and sham-treated groups at 3, 4, 5 and 6 wk post-sham/TAC surgery
| 3 wk Post |
4 wk Post |
5 wk Post |
6 wk Post |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sham | TAC | TAC + T | Sham treated | Sham | TAC | TAC+T | Sham treated | Sham | TAC | TAC + T | Sham treated | Sham | TAC | TAC + T | Sham treated | |
| LV mass, mg | 373.0 ± 27.7 | 606.5 ± 72.0 | 424.4 ± 70.6 | 385.0 ± 30.7 | 419.6 ± 36.5 | 684.8 ± 98.7 | 573.7 ± 58.8 | 385.0 ± 30.7 | 544.7 ± 30.9 | 711.8 ± 77.3 | 735.0 ± 80.4 | 517.2 ± 42.6 | 631.6 ± 32.5 | 1012.0 ± 142.7** | 742.0 ± 58.8‡ | 561.3 ± 65.0 |
| LVID,d, mm | 6.1 ± 0.1 | 5.5 ± 0.3 | 5.0 ± 0.2 | 6.2 ± 0.3 | 6.3 ± 0.1 | 6.1 ± 0.3 | 5.5 ± 0.3 | 6.2 ± 0.3 | 6.6 ± 0.2 | 6.8 ± 0.3 | 6.4 ± 0.4 | 6.4 ± 0.2 | 7.1 ± 0.1 | 7.7 ± 0.5 | 7.3 ± 0.2 | 7.0 ± 0.2 |
| LVID,s, mm | 3.8 ± 0.1 | 3.2 ± 0.3 | 2.9 ± 0.1 | 3.8 ± 0.2 | 3.8 ± 0.1 | 3.7 ± 0.2 | 3.3 ± 0.2 | 3.8 ± 0.2 | 3.8 ± 0.2 | 4.9 ± 0.3* | 4.0 ± 0.4† | 3.9 ± 0.2 | 4.4 ± 0.2 | 5.7 ± 0.5** | 4.5 ± 0.2‡ | 4.2 ± 0.1 |
| LVPW,d, mm | 1.5 ± 0.1 | 1.9 ± 0.2 | 1.9 ± 0.2 | 1.3 ± 0.1 | 1.6 ± 0.1 | 1.9 ± 0.2 | 2.0 ± 0.2 | 1.3 ± 0.1 | 1.6 ± 0.1 | 2.0 ± 0.1 | 2.3 ± 0.2 | 1.6 ± 0.1 | 1.7 ± 0.1 | 2.3 ± 0.3* | 2.0 ± 0.2 | 1.6 ± 0.1 |
| IVS,d, mm | 1.3 ± 0.1 | 1.7 ± 0.2 | 1.7 ± 0.2 | 1.3 ± 0.1 | 1.4 ± 0.1 | 1.8 ± 0.2 | 1.8 ± 0.1 | 1.3 ± 0.1 | 1.5 ± 0.0 | 1.9 ± 0.2 | 2.2 ± 0.3 | 1.5 ± 0.1 | 1.5 ± 0.0 | 2.2 ± 0.2* | 2.3 ± 0.2* | 1.6 ± 0.1 |
| HR, beats/min | 471.1 ± 9.3 | 399.5 ± 28.0 | 424.6 ± 5.5 | 467.7 ± 11.0 | 463.9 ± 6.3 | 391.3 ± 25.7 | 441.8 ± 19.0 | 467.7 ± 11.0 | 438.6 ± 8.9 | 322.5 ± 29.0* | 346.8 ± 44.3 | 460.5 ± 11.5 | 434.0 ± 12.8 | 325.6 ± 34.5** | 365.4 ± 34.7 | 433.8 ± 15.9 |
| E/A ratio | 1.8 ± 0.14 | 1.75 ± 0.11 | 1.93 ± 0.24 | 1.68 ± 0.2 | 1.78 ± 0.13 | 1.87 ± 0.2 | 2.1 ± 0.24 | 1.68 ± 0.2 | 1.76 ± 0.07 | 1.57 ± 0.1 | 1.7 ± 0.12 | 1.65 ± 0.11 | 1.72 ± 0.1 | 1.97 ± 0.1 | 2.27 ± 0.4 | 1.65 ± 0.2 |
| PR interval, s | 0.04 ± 0.0 | 0.03 ± 0.0 | 0.03 ± 0.0 | 0.03 ± 0.0 | 0.03 ± 0.0 | 0.03 ± 0.0 | 0.04 ± 0.0 | 0.03 ± 0.0 | 0.03 ± 0.0 | 0.04 ± 0.0* | 0.04 ± 0.0 | 0.03 ± 0.0 | ||||
Values are means ± SE; n, number of subjects. HR, heart rate; IVS,d, interventricular septal thickness in diastole; LVID,d, left ventribular (LV) internal diameter in diastole; LVID,s LV internal diameter in systole; LVPW,d, LV posterior wall thickness in diastole; TAC, transaortic constriction; TAC + T, TAC + treatment. No. of animals in each group are as follows: sham (n = 8), TAC (n = 6), TAC + T (n = 6), and Sham treated (n = 5). Ratio of early (E) to late (A) mitral inflow (E/A).
*
P < 0.05, sham vs. TAC;
**
P < 0.01, sham vs. TAC;
†
P < 0.05, untreated TAC vs. TAC + treatment;
‡
P < 0.01, untreated TAC vs TAC + treatment.