Fig. 1.

Donor condition impacts transcriptional signature of cardiac mesenchymal cells (CMCs). Total RNA was isolated from CMCs derived from sham (Sham-CMC; n = 3) and heart failure mice (HF-CMC; n = 3) and was subjected to unbiased RNA-seq analysis to characterize global transcriptional changes. A: heat map analysis showing upregulated genes. B: heat map analysis showing downregulated genes. C: Gene Ontology (GO) enrichment analysis showing top upregulated genes. D: GO enrichment analysis showing top downregulated genes. A test statistic was used to determine significance of differentially expressed genes in Sham-CMC and HF-CMC groups. A Fisher’s exact test was used to determine significantly enriched GO terms.