Fig. 7.

Administration of heart-derived cardiac mesenchymal cells (Sham-CMCs) reduced immune cell abundance in the infarct zone of the heart. Sections from saline (vehicle; n = 9)-, sham (Sham-CMC; n = 9)-, and heart failure (HF-CMC; n = 9)-treated hearts were stained with CD45 antigen to assess presence of leukocytes. A: representative images of vehicle-, Sham-CMC-, and HF-CMC-treated hearts. B: quantification of CD45 (red) cells in the border zone (BZ), infarct zone (IZ), and remote zone (RZ) of treated hearts. Data are represented as means ± SD. Two-way ANOVA followed by Tukey’s multiple-comparison test was used to determine significant differences between Sham-CMC- or HF-CMC-treated hearts compared with vehicle in the BZ, IZ, and RZ.