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. Author manuscript; available in PMC: 2020 Sep 5.
Published in final edited form as: Nat Rev Gastroenterol Hepatol. 2020 Mar 9;17(6):338–351. doi: 10.1038/s41575-020-0271-2

Fig. 1: Key developments in the enteric nervous system.

Fig. 1:

The figure shows the timeline of the major advances made in our understanding of the enteric nervous system (ENS) and the identification of motility reflexes. The first evidence of a reflex response in an isolated segment of the gut was provided in 1755 by Von Haller1. It was not until 1995 that the first unequivocal evidence that the ENS contained its own population of sensory neurons was presented2. For Cannon, Legros & Onimus and Langley see refs181,182,183