Table 2.

Definitions used for establishing organic dysfunction

Sepsisa	Strongly suspected or confirmed infectious source on admission AND A change in baseline of the total SOFA (Sequential Organ Failure Assessment) score of ≥ 2 points
Septic shocka	Persisting hypotension requiring vasopressors to maintain mean arterial pressure ≥ 65 mmHg; OR Serum lactate level > 2 mmol/L despite adequate volume resuscitation;
Cardiogenic shockb	Compatible clinical situation; AND Systolic blood pressure < 90 mmHg with adequate volume; AND Clinical or laboratory signs of hypoperfusion;
Hypovolemic shockb	Evidence of fluid loss, in the absence of infection or heart failure; AND Systolic blood pressure < 90 mmHg; OR Serum lactate level > 2 mmol/L;
Cardiovascular dysfunctiona	Systolic blood pressure < 90 mmHg or Mean arterial pressure < 65 mmHg or lactate > 2.0 mmol/L (after initial fluid challenge)
Renal dysfunctionc	Stage 1: SCr1.5–1.9 times baseline or ≥ 0.3 mg/dl increase or urinary flow ≤ 0.5 ml/kg/h for 6–12 h; Stage 2: SCr 2.0–2.9 times baseline or ≤ 0.5 ml/kg/h for ≥ 12 h Stage 3: SCr 3.0 times baseline or Increase in serum creatinine to ≥ 4.0 mg/dl or Initiation of renal replacement therapy or Decrease in eGFR to < 35 ml/min/1.73m2 or urinary flow ≤ 0.3 ml/kg/h for ≥ 24 h or Anuria for ≥ 12 h;
Hematologic dysfunctiona	Platelets < 150 × 103/μl or prolonged prothrombin time ≥ 2 s
Hepatic dysfunctiona	Serum bilirubin ≥ 2 mg/dl
Respiratory dysfunctiond	Impaired oxygenation of acute onset:  Moderate—PaO2/FiO2 ratio 100–200  Severe—PaO2/FiO2 ratio < 100
Neurological dysfunctiona	Decrease in 1 point from basal GCS

eGFR Estimated glomerular filtration rate, FiO2 fraction of inspired oxygen, P_aO2 partial arterial oxygen pressure, SCr Serum Creatinine

^aDefined according to the SEPSIS-3 definitions¹⁵

^bDefined according to the Consensus on circulatory shock and hemodynamic monitoring¹⁷

^cDefined according to the KDIGO guidelines on Acute Kidney Injury²⁰

^dDefined according to the Acute respiratory distress syndrome: the Berlin Definition¹⁹