Table 4.
Analysis of endothelial dysfunction markers and organic dysfunctions
| ln(RHI) | ln(Endocan) (pg/mL) | Ln(sE-Selectin) (pg/mL) | Ln(Syndecan-1) (pg/mL) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Result | p-value | Result | p-value | Result | p-value | Result | p-value | ||
| Shock | Absent | 0.804 (0.055) | 7.04 (0.11) | 10.46 (0.14) | 8.36 (0.09) | ||||
| Non-septic | 0.422 (0.131) | 0.021‡ | 7.14 (0.29) | 0.943‡ | 10.29 (0.13) | 0.860‡ | 8.68 (0.23) | 0.292‡ | |
| Septic | 0.245 (0.071) | < 0.01‡ | 7.21 (0.19) | 0.617‡ | 11.04 (0.15) | 0.010‡ | 8.85 (0.09) | 0.001‡ | |
| Cardiovascular dysfunction |
Present Absent |
0.404 (0.067) 0.837 (0.046) |
< 0.01† |
7.29 (0.13) 6.80 (0.10) |
0.01† |
10.84 (0.12) 10.34 (0.17) |
0.02† |
8.79 (0.07) 8.18 (0.10) |
< 0.01† |
|
Lactates ≥ 2 mmol/L Lactates < 2 mmol/L |
0.343 (0.082) 0.750 (0.049) |
< 0.01† |
7.48 (0.23) 6.99 (0.09) |
0.030† |
10.98 (0.18) 10.56 (0.12) |
0.071† |
9.03 (0.09) 8.42 (0.08) |
< 0.01† | |
|
MAP < 65 mmHg MAP ≥ 65 mmHg |
0.445 (0.067) 0.750 (0.066) |
< 0.01† |
7.26 (0.16) 6.97 (0.10) |
0.140† |
10.96 (0.13) 10.37 (0.13) |
< 0.01† |
8.79 (0.09) 8.36 (0.10) |
< 0.01† | |
|
SBP < 90 mmHg SBP ≥ 90 mmHg |
0.493 (0.068) 0.671 (0.070) |
0.040† |
7.25 (0.18) 7.01 (0.10) |
0.222† |
11.01 (0.14) 10.39 (0.12) |
< 0.01† |
8.79 (0.09) 8.40 (0.09) |
< 0.01† | |
|
With norepinephrine Without norepinephrine |
0.475 (0.070) 0.676 (0.068) |
0.523† |
7.31 (0.17) 6.94 (0.99) |
0.011† |
10.93 (0.14) 10.43 (0.13) |
0.325† |
8.76 (0.89) 8.41 (0.09) |
0.794† | |
| Norepinephrine dose (mcg/kg/minute) | |||||||||
| 0.001 to 0.199 | 0.628 (0.375) | 0.977‡ | 7.045 (0.928) | 0.971‡ | 10.807 (1.029) | 0.458‡ | 8.535 (0.604) | 0.882‡ | |
| 0.200 to 0.499 | 0.529 (0.300) | 0.666‡ | 7.193 (0.554) | 0.723‡ | 11.107 (0.757) | 0.059‡ | 8.894 (0.418) | 0.044‡ | |
| ≥ 0.500 | 0.265 (0.567) | 0.010‡ | 7.637 (1.171) | 0.025‡ | 10.874 (0.653) | 0.262‡ | 8.824 (0.451) | 0.073‡ | |
| Renal dysfunction |
Present Absent |
0.286 (0.105) 0.700 (0.048) |
< 0.01† |
7.19 (0.21) 7.07 (0.09) |
0.566† |
10.80 (0.17) 10.60 (0.12) |
0.339† |
8.94 (0.11) 8.38 (0.07) |
< 0.01† |
| AKI severity: | |||||||||
| Stage 1 | 0.530 (0.194) | 0.943‡ | 6.72 (0.35) | 0.847‡ | 11.78 (0.68) | 0.047‡ | 8.91 (0.30) | 0.222‡ | |
| Stage 2 | 0.262 (0.128) | 0.009‡ | 7.35 (0.33) | 0.819‡ | 10.52 (0.17) | 0.994‡ | 8.86 (0.18) | 0.102‡ | |
| Stage 3 | 0.223 (0.160) | 0.003‡ | 7.23 (0.31) | 0.898‡ | 10.71 (0.21) | 0.953‡ | 8.90 (0.16) | 0.001‡ | |
| Neurological dysfunction |
Present Absent |
0.556 (0.083) 0.573 (0.070) |
0.961† |
7.00 (0.13) 7.25 (0.14) |
0.211† |
10.79 (0.15) 10.51 (0.12) |
0.159† |
8.56 (0.10) 8.59 (0.10) |
0.798† |
| Respiratory dysfunction |
Present Absent |
0.581 (0.057) 0.557 (0.100) |
0.816† |
7.11 (0.11) 7.12 (0.20) |
0.929† |
10.61 (0.12) 10.79 (0.19) |
0.425† |
8.57 (0.08) 8.57 (0.13) |
0.992† |
| ARDS severity: | |||||||||
|
PaO2/FiO2 200–300% PaO2/FiO2 100–199% PaO2/FiO2 < 99% |
0.618 (0.082) 0.557 (0.086) 0.558 (0.168) |
0.984‡ 0.997‡ 1.000‡ |
7.13 (0.18) 7.01 (0.13) 8.22 (0.66) |
0.999‡ 0.954‡ 0.249‡ |
10.61 (0.22) 10.63 (0.14) 10.29 (0.20) |
0.978‡ 0.924‡ 0.892‡ |
8.50 (0.12) 8.60 (0.12) 8.87 (0.33) |
0.909‡ 0.930‡ 0.848‡ |
|
| Hepatic dysfunction |
Present Absent |
0.550 (0.119) 0.570 (0.060) |
0.868† |
7.18 (0.19) 7.09 (0.11) |
0.668† |
10.97 (0.18) 10.54 (0.12) |
0.047† |
8.93 (0.12) 8.42 (0.07) |
< 0.01† |
| Hematologic dysfunction |
Present Absent |
0.554 (0.071) 0.617 (0.065) |
0.939† |
7.12 (0.13) 6.97 (0.13) |
0.257† |
10.80 (0.12) 10.43 (0.16) |
0.078† |
8.71 (0.09) 8.32 (0.10) |
< 0.01† |
|
PT time > 12 s Normal PT time |
0.555 (0.071) 0.617 (0.066) |
0.539† |
7.24 (0.17) 7.02 (0.11) |
0.299† |
10.78 (0.12) 10.58 (0.15) |
0.319† |
8.75 (0.09) 8.43 (0.10) |
0.024† | |
|
PLT ≤ 150 × 103/uL PLT > 150 × 103/uL |
0.536 (0.087) 0.618 (0.054) |
0.415† |
7.25 (0.16) 6.98 (0.11) |
0.165† |
10.85 (0.15) 10.48 (0.13) |
0.066† |
8.78 (0.10) 8.37 (0.08) |
< 0.01† | |
| Severity scores |
APACHEII SAPS2 SOFA |
− 0.453 − 0.359 − 0.314 |
< 0.01* < 0.01* < 0.01* |
0.039 0.083 0.218 |
0.752* 0.501* 0.074* |
0.226 0.229 0.335 |
0.063* 0.060* < 0.01* |
0.340* 0.366* 0.553* |
< 0.01 < 0.01 < 0.01 |
Results are presented as mean (standard deviation) or Pearsons’ r
APACHEII Acute physiology and chronic health evaluation II, ARDS acute respiratory distress syndrome, CV cardiovascular, Ln natural logarithm, MAP mean arterial pressure, PLT platelets, PT prothrombin time, SBP systolic blood pressure, SAPSII simplified acute physiology score II, SOFA sequential organ failure assessment
†Bivariate variables were compared using Students t-test
‡Variables with more than 2 categories were compared with Dunnetts’ test, presented p-values refer to the absence of condition (control)
*For comparisons between continuous variables, the Pearsons’ correlation test was used