TABLE 4:

Risk Score Comparisons and Estimates of the Incremental Effect of Venous Pulsatility Index (VPI)

Comparison or Estimate	Difference in Optimism-Corrected ROC AUCa	P
Risk score comparison
NAFLD FS vs VPI	−0.10 (−0.24 to 0.02)	0.106
FIB-4 vs VPI	−0.03 (−0.16 to 0.09)	0.645
BARD score vs VPI	−0.24 (−0.42 to −0.08)	0.005
APRI vs VPI	−0.12 (−0.26 to 0.01)	0.081
Incremental effect of VPI
VPI + NAFLD FS vs VPI	0.04 (0.00–0.09)	0.088
VPI + NAFLD FS vs NAFLD FS	0.14 (0.06–0.26)	0.002
VPI + FIB-4 vs VPI	0.06 (0.01–0.12)	0.040
VPI + FIB-4 vs FIB-4	0.09 (0.02–0.18)	0.031
VPI + BARD score vs VPI	0.01 (−0.01 to 0.05)	0.493
VPI + BARD score vs BARD score	0.25 (0.12–0.42)	0.001
VPI + APRI vs VPI	0.01 (−0.01 to −0.06)	0.570
VPI + APRI vs APRI	0.13 (0.02–0.27)	0.028

Note—Values in parentheses are 95% CIs. NAFLD FS = nonalcoholic fatty liver disease fibrosis score, FIB-4 = fibrosis-4 index, BARD = body mass index (weight in kilograms divided by the square of height in meters), aspartate aminotransferase (AST)–to–alanine aminotransferase ratio, diabetes mellitus.

^aA negative value in risk score comparison indicates superior diagnostic performance of VPI versus the given clinical risk prediction model.