Table 1.

Summary of recommendations from various guidelines regarding use of immunomodulatory therapy during COVID-19

Drugs	Recommendation
NSAIDs	May be continued, consider stopping in severe infections
Steroids	Use lowest possible dose, avoid sudden discontinuation, low-dose dexamethasone in moderate to severe COVID-19 recommended
csDMARDs	May be continued; consider stopping SSZ, MTX, LEF in documented/presumptive COVID-19
bDMARDs, tsDMARDs	May initiate therapy in moderate to severe rheumatic conditions, withhold all biologics except IL-6 inhibitors in documented/ presumptive COVID-19 Consider switching from intravenous to subcutaneous form if available Consider increasing dosing interval or reduction of RTX dose
Pneumococcal and influenza vaccine, vitamin D	Recommended