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BMAL1 and CRY control of c-MYC expression in mouse spleen (model of circadian regulation of c-MYC). (A) BMAL1 deficiency induces the transcription of Ctnnb1 (β-catenin), which binds the TCF/LEF family of transcription factors resulting in high expression of c-Myc. (B) In the Cry1/2 KO, CLOCK-BMAL1 at its binding site in the Ctnnb1 intron suppresses the transcription of Ctnnb1 (β-catenin), which results in low expression of c-Myc.
