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. 2020 Aug 17;117(35):21527–21535. doi: 10.1073/pnas.2006566117

Fig. 4.

Fig. 4.

(A) Enhanced remyelination in mice treated with anacardic acid and stained with MBP or MOG. (B) Quantitation of MBP and MOG expression from eight animals in the treated group and an equal number of controls (*P < 0.01 myelin antigen staining in anacardic acid treated compared to DMSO). (C–F) EM analysis of remyelination in cuprizone-fed mice treated with anacardic acid. Sagittal section of corpus callosum as stained by osmium tetroxide and the g ratio manually calculated on 150 axons. Distribution of g ratio between anacardic acid treated and DMSO-treated mice (P < 0.001 ANOVA) (C), scatter plot showing the difference in the slope between anacardic acid-treated and vehicle-treated mice (D), and sections of axons in anacardic acid-treated animals (E) and vehicle-treated animals (F). Arrows show the thinning of myelin sheath of axons in vehicle-treated mice.