Table 2.
NTRK2 regional DNA methylation element (chr9:87285001–87290000) associations with lifetime PTSD risk and symptoms
| Sample | Phenotype | t-Statistic | P value | Effect size f2 |
| African sample 1 (n = 463) | PTSD risk | −3.76 | <0.001 | 0.17 (0.10, 0.25) |
| PDS Sum | −3.48 | <0.001 | 0.16 (0.08, 0.24) | |
| Avoidance | −3.50 | < 0.001 | 0.17 (0.09, 0.24) | |
| NTRK2 methylation (0.50 ± 0.08)* | Intrusions | −3.28 | <0.001 | 0.15 (0.07, 0.23) |
| Hyperarousal | −1.45 | n.s. | — | |
| African sample 2 (n = 350) | PTSD risk | −3.07 | 0.002 | 0.18 (0.08, 0.27) |
| PDS Sum | −3.04 | 0.003 | 0.16 (0.07, 0.25) | |
| Avoidance | −3.38 | <0.001 | 0.21 (0.11, 0.31) | |
| NTRK2 methylation (0.50 ± 0.11)* | Intrusions | −2.19 | 0.029 | 0.13 (0.03, 0.24) |
| Hyperarousal | −1.80 | n.s. | — |
Fixed-effects analysis t-statistics and nominal P values are shown. Sum of life traumatic event types was used as a covariate in the multiple regression model. Effect sizes of NTRK2 regional DNA methylation are provided as Cohen’s f2 (90% CI). n.s., not significant.
*
(Mean ± SD).