Table 1.
Prevalence (and Corresponding Expected Number of CRCs) of Early and Advanced Stages for CRCs Detected at Delayed Screening, According to Increasing Time Delays to Access to Colonoscopy (Estimates by DS Meta-analysis)
| Diagnostic delay (mo) | Stage at diagnosis | Stage prevalence | 95% Confidence intervala | Expected CRCsb | P valuec |
|---|---|---|---|---|---|
| 0–3 | I–II | 0.74 | (0.69–0.80) | 2356 | Reference |
| III–IV | 0.26 | (0.20–0.31) | 828 | ||
| 4–6 | I–II | 0.76 | (0.71–0.81) | 2420 | .068 |
| III–IV | 0.24 | (0.19–0.29) | 764 | ||
| 7–12 | I–II | 0.71 | (0.66–0.77) | 2261 | .008 |
| III–IV | 0.29 | (0.23–0.34) | 923 | ||
| >12 | I–II | 0.67 | (0.57–0.77) | 2133 | <.001 |
| III–IV | 0.33 | (0.23–0.43) | 1051 |
CRC, colorectal cancer; DS, delayed stage.
a
Lower and upper limit of 95% confidence interval.
b
Total number of cases is always equal to 3184 for each delay scenario.
c
P values refer to comparison of binomial proportions by stage of expected number of CRCs at 0–3 months vs higher delays on total number of CRC cases (3184), eg, .068 is the P value of the hypothesis test for comparing 2420/3184 vs 2356/3184.