Table 4.

Association of race and PRA categories with hazard of rehospitalization (Cox regression models).

	N	Events	HR (95% CI)	P Value
All-cause hospitalization
Baseline PRA (N=356)
• Non-Black, low PRA	136	41	REFERENCE
• Non-Black, high PRA	136	49	1.43 (0.90 – 2.28)	0.1
• Black, low PRA	40	19	3.14 (1.68 – 5.87)	<0.001
• Black, high PRA	40	20	2.08 (1.13 – 3.83)	0.019
72- to 96-hr PRA (N=310)
• Non-Black, low PRA	87	18	REFERENCE
• Non-Black, high PRA	88	37	2.55 (1.55 – 4.20)	<0.001
• Black, low PRA	24	10	4.51 (2.25 – 9.04)	<0.001
• Black, high PRA	25	13	3.96 (2.02 – 7.75)	<0.001
HF hospitalization
Baseline PRA (N=356)
• Non-Black, low PRA	136	24	REFERENCE
• Non-Black, high PRA	136	25	1.14 (0.62 – 2.12)	0.7
• Black, low PRA	40	9	2.30 (0.98– 5.41)	0.057
• Black, high PRA	40	10	1.58 (0.68 – 3.64)	0.3
72- to 96-hr PRA (N=310)
• Non-Black, low PRA	87	8	REFERENCE
• Non-Black, high PRA	88	19	2.00 (1.04 – 3.83)	0.037
• Black, low PRA	24	4	2.62 (0.95 – 7.23)	0.06
• Black, high PRA	25	6	2.74 (1.09 – 6.94)	0.033

Risk of rehospitalization estimated for subjects enrolled in DOSE-AHF and CARRESS-HF who had measured biomarkers of RAAS activation. PRA was analyzed at baseline for subjects enrolled in DOSE-AHF and CARRESS-HF, and at 72 hr for subjects in DOSE-AHF or 96 hr for subjects in CARRESS-HF. Subjects are classified as high vs. low PRA based on race-specific median values. Models are adjusted for study, age, sex, history of hypertension, blood pressure, HF etiology, ejection fraction, BMI, eGFR, and baseline ACE-I/ARB and aldosterone antagonist use.