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. 2020 Sep 6;183(3):730–738.e13. doi: 10.1016/j.cell.2020.09.018

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© 2020 Elsevier Inc.

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The Native Structure of S2 in the Postfusion Conformation

(A) A representative tomogram slice (5 nm thick), showing a cluster of spikes in the postfusion conformation on a SARS-CoV-2 virion.

(B) 3D reconstructions of S2 in the postfusion state. The boxed region in (A) is reconstructed by projecting the solved postfusion S structure onto the refined coordinates. Resolution, 15.3 Å; threshold, 1.0.

(C) Distribution of the postfusion Ss. Left: statistics indicate that the postfusion Ss are closer to each other on the viral surface compared with the prefusion Ss. Right: viruses possessing less spikes in total tend to have more postfusion Ss (only virions possessing postfusion Ss were counted).

(D) The postfusion S structure fitted with PDB: 6XRA, displaying densities of N1098, N1074, N1158, N1173, and N1194. The density of N1134 is not visible on the map and is colored gray.