Table 3.
Data from the first 7 days after randomization in 306 patients with acute respiratory failure
| Variables | At initiation | At 24 h | Day 2 | Day 4 | Day 7l | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| NAVA | Control | NAVA | Control | NAVA | Control | NAVA | Control | NAVA | Control | |
| N = 153 | N = 153 | N = 153 | N = 153 | N = 130 | N = 140 | N = 93 | N = 105 | N = 61 | N = 75 | |
| SOFA | 6.4 ± 3.1 | 6.8 ± 3.3 | 5.8 ± 3.2 | 6.1 ± 3.1 | 5.2 ± 3.2 | 5.6 ± 2.9 | 5.3 ± 3.5 | 5.5 ± 3.0 | 5.0 ± 3.6 | 5.1 ± 3.1 |
| Tidal volume, ml/kg PBW | 7.4 ± 1.4 | 7.2 ± 1.2 | 6.9 ± 1.8 | 6.9 ± 1.6 | 6.8 ± 1.7 | 6.7 ± 1.5 | 6.8 ± 1.8 | 6.8 ± 1.2 | 6.6 ± 1.7 | 7.0 ± 1.3 |
| Respiratory rate, b/min | 19 ± 6 | 19 ± 5 | 18 ± 6 | 17 ± 5 | 18 ± 6 | 17 ± 5 | 18 ± 5 | 19 ± 5 | 20 ± 6 | 19 ± 5 |
| PEEP, cmH2O | 8 ± 2 | 8 ± 3 | 8 ± 2 | 8 ± 2 | 8 ± 2 | 8 ± 3 | 8 ± 3 | 8 ± 3 | 8 ± 3 | 9 ± 3 |
| Peak inspiratory pressure¶ | 22 ± 7 | 24 ± 7 | 19 ± 6 | 21 ± 6 | 18 ± 6 | 20 ± 7 | 20 ± 7 | 21 ± 7 | 20 ± 7 | 21 ± 6 |
| Plateau pressure, cmH2O | 19 ± 5 (n = 105) | 21 ± 5 (n = 128) | 16 ± 5 (n = 79) | 17 ± 5 (n = 113) | 16 ± 6 (n = 64) | 17 ± 7 (n = 97) | 17 ± 6 (n = 47) | 19 ± 5 (n = 61) | 18 ± 6 (n = 29) | 19 ± 5 (n = 37) |
| NAVA level | 1.7 ± 1.6 | – | 1.7 ± 1.2 | – | 1.6 ± 1.2 | – | 1.5 ± 1.1 | – | 1.5 ± 1.7 | – |
| Edi max | 15 ± 12 | – | 15 ± 10 | – | 16 ± 11 | – | 17 ± 10 | – | 17 ± 10 | – |
| FiO2 | 0.44 ± 0.09 | 0.47 ± 0.12 | 0.45 ± 0.11 | 0.46 ± 0.13 | 0.44 ± 0.11 | 0.45 ± 0.13 | 0.46 ± 0.13 | 0.46 ± 0.13 | 0.48 ± 0.16 | 0.47 ± 0.14 |
| PaO2, mmHg | 106 ± 31 | 109 ± 36 | 107 ± 29 | 108 ± 31 | 112 ± 37 | 109 ± 32 | 111 ± 34 | 103 ± 28 | 113 ± 30 | 110 ± 47 |
| PaO2/FiO2, mmHg | 250 ± 87 | 244 ± 88 | 254 ± 82 | 254 ± 82 | 262 ± 89 | 261 ± 79 | 255 ± 89 | 245 ± 83 | 254 ± 87 | 247 ± 70 |
| PaCO2, mmHg | 43.1 ± 7.6 | 44.8 ± 9.8 | 43.4 ± 8.1 | 42.8 ± 8.3 | 43.0 ± 7.8 | 42.6 ± 7.6 | 42.8 ± 8.4 | 42.9 ± 7.4 | 43.2 ± 9.8 | 42.6 ± 7.3 |
| pH | 7,41 ± 0.09 | 7.39 ± 0.08 | 7.43 ± 0.08 | 7.43 ± 0.07 | 7.44 ± 0.08 | 7.43 ± 0.07 | 7.44 ± 0.07 | 7.43 ± 0.06 | 7.43 ± 0.08 | 7.43 ± 0.06 |
| Ventilatory mode, N | ||||||||||
| Volume control | 68 | 26 | 20 | 16 | 4 | |||||
| Pressure control | 15 | 5 | 4 | 6 | 5 | |||||
| Pressure support | 27 | 90 | 90 | 48 | 30 | |||||
| PRVC | 43 | 23 | 16 | 13 | 11 | |||||
| SIMV | – | 5 | 6 | 9 | 8 | |||||
Data are mean ± SD. PBW predictive body weight, PEEP positive end-expiratory pressure, PRVC pressure-regulated volume control, SIMV synchronized intermittent mandatory ventilation, SOFA Sequential Organ Failure Assessment score were measured in 6 organ system failures (respiratory, cardiovascular, hematologic, liver, kidney, and neurologic system) with each organ scored from 0 to 4 [19]. In some cells, the denominator differs from the stated patient population because data were not always available for the whole population
¶Peak inspiratory pressure was significantly lower in the NAVA group at 24 h (p = 0.0038) and at day 2 (p = 0.0126) after randomization