Table 1. Summary of breast cancer animal models.

Model		Method	References
Spontaneous		No treatment	Rao et al., 1987
Induced	Chemical	DMBA or MNU	Chan et al., 2007
	Physical	Radiation	Russo & Russo, 1996
	Biological	Lentivirus infection	Bu et al., 2009; Fisher et al., 1999
Transplantation	Homeotransplantation	Spontaneous or induced breast cancer cells transplanted into same strain	Paschall & Liu, 2016
	Heterograft	Human breast cancer cells or patient tumor tissues transplanted into immunodeficient animals	Burdall et al., 2003
Genetic engineering mouse model	Transgenic	Oncogene activation	Rashid & Takabe, 2015
	Knockout	Tumor suppressor gene inactivation	Hutchinson, 2000