. 2020 Sep 18;41(5):477–494. doi: 10.24272/j.issn.2095-8137.2020.095

Table 5. Characteristics of commonly used human breast cancer cell lines.

Name	Origin	Subtype	Pathology	Transplant site	Number of tumor cells	Mouse strain	Latency	Metastasis	Metastasis site	References
AC: Adenocarcinoma; IDC: Invasive ductal carcinoma; C: Carcinoma; DC: Ductal carcinoma; a: Incubation period required for tumor to grow to about 1 cm; b: Mice were implanted with silastic pellets containing cellulose (10 mg) or 17 h-estradiol (2 mg+8 mg cellulose); c: T47D cells stably transfected with constitutively active fibroblast growth factor 2; d: Day; w: Week; m: Month.
BT20	Breast	Basal	IDC	Subcutaneous	6.25×10⁶	Nude mice	3 w	No		Ozzello et al., 1974
BT474	Breast	Luminal B	IDC	Left ventricle	1×10⁶	Nude mice		Yes	Bone	Lu et al., 2009; Neve et al., 2006
MCF-7	Pleural effusion	Luminal A	IDC	Mammary gland fat pad	1×10⁶	Ovariectomized female athymic nude mice^b	1 w	Yes	Lymph nodes, lymph vessels	Harrell et al., 2006
MDA-MB-231	Pleural effusion	Basal	AC	Tail vein	2×10⁵	Immunodeficient mice	8–15 w	Yes	Lung, liver	Bos et al., 2009; Cailleau et al., 1974; Minn et al., 2005;
				Mammary gland fat pad	0.5~1×10⁶		5–9 w		Lung, liver, brain
				Left ventricle	0.1~1×10⁵		4 w		Brain, bone
MDA-MB-453	Pleural effusion	HER2+	AC	Mammary gland fat pad	1×10⁵	NOD/SCID	4 w	Yes	Bone	Charafe-Jauffret et al., 2009; Neve et al., 2006
MDA-MB-435	Pleural effusion	Basal	IDC	Mammary gland fat pad	5×10⁶	NCr-nu/nu nude mice		Yes	Lung	Liby et al., 2003
MDA-MB-361	Breast	Luminal B	AC							Neve et al., 2006
MDA-MB-468	Pleural effusion	Basal	AC							Neve et al., 2006
SUM149	Breast	Basal	DC	Mammary gland fat pad		NOD/SCID	(6–8 w)^a	Yes	Lung	Kuperwasser et al., 2005
SUM185	Pleural effusion	Luminal A	DC							Neve et al., 2006
SUM190	Breast	Basal	C	Mammary gland fat pad		NOD/SCID	(6–8 w)^a			Kuperwasser et al., 2005
SUM1315	Skin	Basal	IDC	Mammary gland fat pad		NOD/SCID	(8–12 w)^a	Yes	Lung, bone	Kuperwasser et al., 2005
SUM52	Pleural effusion	Luminal	C							Ethier et al., 1996
T47D^c	Pleural effusion	Luminal A	IDC	Mammary gland fat pad	1×10⁶	NOD/SCID				Cerliani et al., 2011
SKBR3	Pleural effusion	HER2+	AC							Trempe, 1976
ZR-75-1	Ascites	Luminal B	IDC							Engel et al., 1978
HCC1806		Basal		Subcutaneously	1.7×10⁶	Nude mice	5 d			Wang et al., 2015
HCC1937	Breast	Basal	DC	Mammary gland	5×10⁶	NOD/SCID	10 d			Jia et al., 2016; Neve et al., 2006