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. 2020 Apr 24;37(9):2531–2548. doi: 10.1093/molbev/msaa104

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© The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 4. — NOTCH2NLC configuration in Denisova3 compared with modern humans. (A) Plot showing the Exon1^C-(X-low) allele count for modern humans, ancient humans, Neanderthals, and Denisovan. Note the unusual allele count for Denisovan. (B) Modern human’s median allele count plotted for each of the NOTCH2NLC-specific SUNs distributed along the NOTCH2NL locus. Vertical dashed lines indicate the region around Exon1. Zoom-in shows SUN count in Exon1, including the Exon1^C-(X-low) variant indicated by green arrowhead. (C) NOTCH2NL allele counts in the Denisova3 genome, estimated from the average density of paralog-specific SUNs. (D) Denisova3 allele count plotted for each of the NOTCH2NLC-specific SUNs distributed along the NOTCH2NL locus. Zoom-in shows NOTCH2NLC SUN count in Exon1, including the Exon1^C-(X-low) variant as indicated by green arrowhead.