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Organization of SCOP and CATH databases: SCOP (Andreeva et al. 2019) arranges protein structures into classes, Folds, Superfamilies, and Families. CATH (Sillitoe et al. 2019) uses Classes, Architectures, Topologies, and Homologies to organize protein structures. The horizontal split marks a boundary which separates structure- and evolution-based groupings. Structures grouped together in Homology (CATH) and Family and Superfamily (SCOP) likely share a common evolutionary origin.
