Fig. 4.

Phylogenetic trees for proteins from the aldo-keto reductase (NADP) family built using structural data sets that comprise the indicated fraction of each structure (red) together with the complete structures (black). Only trees built from five of the fractional structural data sets are shown here; enlarged versions of all ten are provided in supplementary figures S23–S32, Supplementary Material online. (a) For fractional structures comprising up to 50% of the complete structure, fraction size dominates the tree structure. Clade groupings are sometimes reproduced for fractional structures comprising (b) 50% to (c) 80% of each protein, but residual differences to (e) the true tree remain even for (d) 90% fractional structures.