Table 2.
Continuous Performance Task Performance in the Healthy, All Bipolar, Lithium-Treated, and Quetiapine-Treated Adolescents
| Variable | Healthy (n = 57) | All Bipolar (n = 79) | Lithium (n = 30) | Quetiapine (n = 49) |
|---|---|---|---|---|
| Baseline performance | ||||
| Average reaction time, ms, mean (S.D.) | 562 (93) | 562 (84) | 555 (82) | 566 (86) |
| % correct, mean (S.D.)a | 88.6 (8.0) | 84.4 (12.3) | 84.6 (11.5) | 84.3 (12.8) |
| % false alarm, mean (S.D.) | 0.9 (1.7) | 1.3 (3.2) | 0.6 (0.5) | 1.8 (4.0) |
| Discriminability, mean (S.D.)b | 0.969 (0.022) | 0.955 (0.040) | 0.959 (0.030) | 0.953 (0.045) |
| Change in performance from baseline to week 6 | ||||
| Average reaction time, ms, mean (S.D.) | −15 (51) | −1 (58) | 7 (72) | −6 (47) |
| % correct, mean (S.D.) | 1.3 (8.3) | −0.2 (11.3) | −3.2 (11.7) | 1.6 (10.7) |
| % false alarm, mean (S.D.) | −0.5 (1.7) | −0.5 (11.3) | −0.1 (0.7) | −0.7 (2.8) |
| Discriminability, mean (S.D.)c | 0.005 (0.020) | 0.001 (0.031) | −0.008 (0.030) | 0.007 (0.030) |
a
Significant difference, ANOVA: F(1, 134) = 5.112, p = 0.025, healthy > all bipolar.
b
Significant difference, ANOVA: F(1, 134) = 5.358, p = 0.022, healthy > all bipolar.
c
Significant difference, ANOVA: F(2, 133) = 3.071, p = 0.050, quetiapine > lithium.
ANOVA, analysis of variance; S.D., standard deviation.