Table 1.

Summary of ²¹¹At-Labeled Mu-81C6 Antibody 81C6 Production Runs

						Radiochemical purity (%)
Exp #	Initial activity (MBq)	To SEC column (MBq)	Labeled mAb (MBq)	mAb conjugation yielda(%)	Overall yieldb(%)	ITLC	MeOH precipitation	SEC	SDS-PAGE	IRF (%)
						1	337.8	166.1	70.7		44	25	95.0	98.3	ND	ND	ND
2	408.5	263.8	112.9	44	32	100.0	99.1	ND	94.5	ND
3	314.9	178.7	81.8	47	30	98.5	99.4	ND	96.0	ND
4	429.9	246.8	99.2	41	27	99.4	99.5	ND	97.0	ND
5	583.1	437.3	213.9	50	42	99.5	98.2	ND	100.0	92
6	822.1	552.4	210.2	39	30	97.8	98.4	ND	100.0	98
7	2033.1	1239.5	694.5	58	38	ND	84.5	ND	ND	93
8	523.6	437.3	303.4	71	65	ND	95.6	100.0	ND	85
9	1678.3	1169.2	704.1	62	47	ND	97.6	98.6	ND	80
10	2740.2	1793.8	1024.5	58	42	ND	91.6	98.9	ND	92
11	425.5	255.3	254.9	100	69	ND	ND	ND	ND	ND

^aCalculated as fraction of activity added to the size-exclusion column eluted as labeled mAb; decay corrected.

^bCalculated as fraction of initial activity isolated as labeled mAb; decay corrected.

mAb, monoclonal antibody; SDS-PAGE, sodium dodecyl sulfate-polyacrylamide gel electrophoresis.