Table 1.

Summary of current status of some protein vaccine candidates against Schistosomiasis.

Ag	Location	Function	Target species	Delivery system	Adjuvant	Host	Development Stage	References
FABP	Tegument and gut epithelium of cercaria, adult, and schistosomula	Absorbs, transports, compartmentalizes FAs from the host	Sm	IM	GLA-SE	Human	Phase I/II	(Santini-Oliveira et al., 2016; Molehin et al., 2016)
TSP2	Tegument apical membrane	Tegument formation and maturation of adult worm	Sm	–	Alum	Human	Phase 1	(Insitute, 2017)
Pmy	Muscle of adults, tegumental of schistosomula and in penetration glands of cercariae	inhibits complement activation; host immune evasion	Sm	IP	_	Swiss Albino mice	Pre-clinical	(Diab and Aly, 2011)
Sm-p80	Tegument of all stages and inner tegument of adult worms	Surface membrane biogenesis and renewal	Sm	IM	GLA-Alum	mouse, hamster &baboon	Pre-clinical	(Zhang et al., 2018)
Sm29	Tegument of adult and schistosomula	Unknown	Sm	_	Alum	BALB/c Mice	Pre-clinical	(Alves et al., 2018)
SmCB1 & SmCL3	Parasite gut and somatic extracts	Feeding and degradation of host blood protiens	Sm & Sh	SC	_	Hamster & mice	Pre-clinical	(Tallima et al., 2017)

IM-Intramuscularly, IP- Intraperitoneally, SC- Subcutaneously, Sm- S. mansoni, Sh- S.haematobium.