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. 2020 Sep 7;9:16. doi: 10.1186/s13619-020-00055-3

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Susceptibility of ICCs to cytotoxicity in term of LDH release with the treatment of ferroptosis inducer, erastin and inhibitor, ferrostatin-1 (Fer-1). a ICCs were challenged with 20 μM or 50 μM erastin for 24 h. b ICCs were administrated with 1 μM, 5 μM or 10 μM Fer-1 for 24 h. c ICCs were treated with 20 μM erastin in the presence or absence of 5 μM Fer-1 for 24 h. The cell free supernatants were harvested for the measurement of LDH release and the viability of ICCs was expressed in percent of cytotoxicity. The experimental groups were analyzed and compared to the respective non-treatment controls. (n = 5 per group; *p < 0.05, **p < 0.01, ***p < 0.001. All data are expressed as means ± SEM)