Fig. 6.

Schematic of the underlying mechanism for ischemic stroke-induced cardiac dysfunction in the diabetic mouse. M1-polarized macrophage infiltration and NLRP3 inflammasome activation in the heart after ischemic stroke induce cardiac dysfunction. Diabetes mellitus exacerbates the cardiac dysfunction after ischemic stroke through increased M1-polarized macrophage infiltration and NLRP3 inflammasome activation in the heart. NLRP3, NLR pyrin domain containing 3; ASC, apoptosis-associated speck-like protein containing a CARD.