Table 2.
Cytotoxic activity of selected compounds isolated from C. incisa leaves.
| Compoundsa | IC50 (μg/mL) |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HepG2 | SI | Hep3B | SI | Hela | SI | PC3 | SI | MCF7 | SI | A549 | SI | IHH | |
| (2) | 75 ± 6 | 1.33 | 73 ± 7 | 1.37 | 82 ± 8 | - | 75 ± 5 | - | ND | - | >100 | - | 100 |
| (3) | ND | - | 55 ± 5 | 1.82 | ND | - | 53 ± 4 | - | ND | - | ND | - | 100 |
| (3Ac) | 50 ± 3 | 1.56 | 49 ± 4 | 1.59 | 63 ± 7 | - | 43 ± 4 | - | - | 87 ± 8 | - | 78 ± 7 | |
| (4) | >100 | - | >100 | - | >100 | - | >100 | - | >100 | - | >100 | - | >100 |
| (4Ac) | >100 | - | >100 | - | >100 | - | >100 | - | >100 | - | >100 | - | >100 |
| (5) | >100 | - | >100 | - | >100 | - | >100 | - | >100 | - | >100 | - | >100 |
| Paclitaxel | 64 × 10−3 | 1.24 | 33 × 10−3 | 2.41 | 4.78 × 10−3 | - | 10.2 × 10−3 | - | 4.27 × 10−3 | - | 5.12 × 10−3 | - | 79.4 × 10−3 |
a
2,3-dihydroxypropyl tetracosanoate (2); β-sitosterol-D-glucopyranoside (3); β-sitosteryl β-D-tetraacetyl glucopyranoside (3Ac); α-amyrin-3-O-β-D-glucopyranoside (4); α-amyrin tetraacetyl 3-O-β-D-glucopyranoside (4Ac); cerebrosides (5).