Fig. 5.
Evaluation of antitumor activity of 13-mG2a-f in SAS xenografts. (A) Tumor volume of SAS xenografts. SAS cells (5 × 106 cells) were injected subcutaneously into the left flank. After eight days, 100 μg of 13-mG2a-f or control mouse IgG in 100 μl PBS were injected i.p. into treated and control mice, respectively. Additional antibodies were then injected on days 14 and 21. Tumor volume was measured on days 8, 14, 17, 21, and 23. Values are mean ± SEM. Asterisk indicates statistical significance (**P < 0.01, n.s: not significant, ANOVA and Sidak's multiple comparisons test) (B) Tumor weights of SAS xenografts. Tumors of SAS xenografts were resected from 13-mG2a-f and control mouse IgG groups. Tumor weight on day 23 was measured from excised xenografts. Values are mean ± SEM. Asterisk indicates statistical significance (*P < 0.05, Welch's t-test). (C) Resected tumors of SAS xenografts from 13-mG2a-f and control mouse IgG groups on day 23.