Table 6. Haplotype association of MDM2 htSNPs with lung cancer risk^a.

Haplotypeb	Constructionc	Case frequency	Control frequency	OR (95% CI)	P value
1	AGCAA	0.476	0.4844	1.00 (Reference)	–
2	ATAGA	0.1303	0.1403	1.00 (0.77–1.28)	0.98
3	GGAGA	0.1456	0.1219	1.17 (0.91–1.51)	0.23
4	GGCGA	0.1021	0.1073	0.97 (0.73–1.29)	0.82
5	AGCGA	0.0279	0.0552	0.52 (0.33–0.82)d	0.0053d
6	AGAGA	0.0284	0.0311	1.07 (0.64–1.79)	0.79
7	ATCGA	0.0242	0.0142	1.64 (0.81–3.31)	0.17
8	AGAGG	0.0196	0.0121	1.41 (0.72–2.76)	0.32
9	AGAAA	0.009	0.0164	0.54 (0.23–1.29)	0.17
Rare	–	NA	NA	2.23 (1.21–4.09)d	0.0099d

^a, global haplotype association P value: 0.0036, adjusted for smoking duration; ^b, five-locus order: rs1690924-rs1846402-rs2291857-rs3730581-rs3730635; ^c, underlined indicates minor allele; ^d, statistical significance.